Each episode of the yet-to-be-named show will see Letterman conduct a long-form interview with a single guest and leave the studio to explore topics on his own.
In his 33 years on late-night television, David Letterman hosted 6,028 episodes of Late Night (NBC) and The Late Show (CBS), and is the longest-running late-night broadcaster in American history.
His career saw him share the stage with U.S. presidents, cabinet officials, Medal of Honor recipients, and almost every presidential candidate for more than 20 years.
Letterman said: “I feel excited and lucky to be working on this project for Netflix.
“Here’s what I have learned, if you retire to spend more time with your family, check with your family first. Thanks for watching, drive safely.”
“Just meeting David Letterman was a thrill; imagine how exciting it is for me to announce that we will be working together,” said Ted Sarandos, Chief Content Officer, Netflix.
“David Letterman is a true television icon, and I can’t wait to see him out in the wild, out from behind the desk and interviewing the people he finds most interesting.
“We’ll have to see if he keeps the beard.”
The series is set to premiere in 2018 and is being produced by RadicalMedia. the Academy Award and Emmy-winning company behind Netflix’s What Happened, Miss Simone?, Oh Hello on Broadway and Abstract: The Art of Design, and Letterman’s Worldwide Pants.